Losing weight can be challenging for many people, especially those struggling with obesity. However, recent scientific breakthroughs have led to the development of new weight loss medications like Tirzepatide, brand name Mounjaro. Let’s will explore what Tirzepatide is, how it works in the body, clinical trials conducted, potential side effects and risks, and who can benefit from using it.

What is Tirzepatide?

Tirzepatide is a medication that belongs to a class of drugs called glucagon-like peptide-1 (GLP1) receptor agonists. It is designed to work by regulating blood sugar levels, reducing appetite, and promoting satiety to help people lose weight. Tirzepatide works by binding to and activating GLP1 and glucose-dependent insulinotropic peptide (GIP) receptors, which are located in the brain and gut. This action leads to a reduction in hunger, increased feeling of fullness, and regulation of blood sugar levels. At higher doses,

Clinical Trials and Results

Several clinical trials have been conducted to test the effectiveness of Tirzepatide in promoting weight loss. In a recent study, people who took Tirzepatide lost an average of 14.9% of their body weight, which is significantly more than the 2.4% weight loss achieved by those taking a placebo. This makes Tirzepatide one of the most effective weight loss medications currently available. Additionally, Tirzepatide has also been shown to improve other health markers, such as blood sugar control, blood pressure, and cholesterol levels.

Mechanism of Action

Tirzepatide works by activating GLP1, GIP, and glucagon receptors in the body. GLP1 and GIP are hormones produced by the gut in response to food intake, which stimulate the release of insulin and promote satiety. It is a peptide that works like a special key that can fit into certain locks in our body. It targets and activates the GLP1 (glucagon-like peptide-1) receptors and the GIP (glucose-dependent insulinotropic peptide) receptors.

These receptors are found in different parts of our body, including the brain and the gut.

When Tirzepatide activates the GLP1 receptors in our brain, it sends a signal to reduce our appetite and make us feel less hungry. It’s like flipping a switch that tells our brain, “You don’t need to eat as much right now.”

Simultaneously, Tirzepatide activates the GIP receptors in our gut. This helps our body release more insulin when we eat. Insulin is a hormone that helps regulate our blood sugar levels. By increasing insulin release, Tirzepatide helps keep our blood sugar levels in a healthy range.

Side Effects and Risks Associated with Use

Like any medication, Tirzepatide may cause side effects. Some of the most common side effects include nausea, vomiting, diarrhea, and constipation. In rare cases, Tirzepatide may also cause pancreatitis, a potentially life-threatening condition. It is important to talk to your provider about any potential risks associated with taking Tirzepatide and to follow your dosage instructions carefully. Patients typically start out at a lower dose for a few weeks while they are getting used to the medication and work their way up to a dose that promotes weight loss. At much higher doses, there is risk for low blood sugar but these doses are not typically used for weight loss.

Who Can Benefit from Using Tirzepatide?

Tirzepatide is most effective for people with a body mass index (BMI) of 30 or higher, or those with a BMI of 27 or higher who also have other health conditions such as diabetes or high cholesterol levels. Tirzepatide is not recommended for people with a history of pancreatitis or thyroid cancer.

Conclusion

Tirzepatide is a promising new weight loss medication that works to regulate blood sugar levels, reduce appetite, and promote satiety. While it is an effective tool for healthy weight loss, it is important to understand the potential side effects and risks associated with its use. Active calorie deficit is still necessary for successful weight loss results. At Venture Wellness we offer a ongoing coaching and support prior to starting and during your medication to set you up for success!